Glutamate Receptors: Desensitizing Dimers
نویسنده
چکیده
Recent structural studies show, not only how the desensitization of a ligand-gated ion channel with bound agonist can be rationalized in terms of subunit-subunit instability, but also how a previously unknown mode of interaction may provide clues into how the receptor is tetramerically assembled in vivo.
منابع مشابه
Desensitizing interactions
of receptor desensitization. Mutations that strengthen this interaction are more resistant to desensitization, whereas disruption of dimerization promotes desensitization. Dimer interaction takes place between domain 1 of the ligand-binding core in each subunit. When these interactions are strong, These studies also explain the mode of action of a drug that promotes AMPA activation, cyclothiazi...
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ورودعنوان ژورنال:
- Current Biology
دوره 12 شماره
صفحات -
تاریخ انتشار 2002